This document provides information on screening for substance use in specialty populations, specifically adolescents and pregnant women. It discusses the importance of screening in these groups due to risks of substance use on development and health. Validated screening tools for each population are described, including the CRAFFT for adolescents and T-ACE and TWEAK for pregnant women. The document emphasizes the need for non-judgmental, universal screening during healthcare visits to properly identify and address substance use issues.