This document discusses using Microsoft Azure cloud computing resources to conduct genome-wide association studies (GWAS) and polygenic risk scoring (PRS) to predict COVID-19 mortality. Key steps include acquiring genotype and phenotype data, performing quality control, running GWAS and PRS analyses using HPC clusters on Azure, and downloading results. Azure provides scalable computing and storage for the large genomic datasets. Its HPC capabilities allow accelerating the analyses, which could otherwise take months to complete on-premises.