This document discusses strategies to prevent device and procedure-associated infections in healthcare settings. It covers general guidelines for handling and reprocessing reusable medical items to minimize risks. Specific interventions are described to prevent common healthcare-associated infections like catheter-associated urinary tract infections, central line-associated bloodstream infections, and surgical site infections. Care bundles are highlighted as sets of evidence-based practices that improve outcomes when implemented collectively. The document provides information on indications for medical devices and strategies to limit unnecessary use.