The document discusses the benefits and challenges of implementing a full-XML workflow for the Proceedings of the National Academy of Sciences (PNAS) journal. PNAS has a large volume of diverse research articles and supporting information that requires complex production workflows. While converting between XML formats from their peer review system to their online host presents challenges, a full-XML workflow would allow for better search capabilities, customized content delivery, and new features for supporting information. The document recommends planning XML integration early, involving all stakeholders, considering future possibilities, and focusing on goals rather than technical details.