This study examines the effect of macroeconomic variables (inflation, interest rates, money supply, exchange rates) on stock returns of companies listed on the Indonesia Stock Exchange from November 2016 to June 2018. Using multiple linear regression analysis on monthly data, the study found that macroeconomic variables have a significant effect on stock returns. Specifically, changes in inflation rates, interest rates, money supply, and the Rupiah exchange rate influence the overall stock price index and company stock returns in Indonesia. The results indicate macroeconomic conditions impact stock market performance.