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Stem Cell Therapy of Spinal Cord Injury
This document discusses potential stem cell sources and treatments for spinal cord injury. It summarizes preclinical studies showing umbilical cord blood cells improve recovery when transplanted shortly after spinal cord injury in rat models. Recent clinical trials have transplanted umbilical cord blood cells into humans with chronic spinal cord injury. The document also discusses that lithium treatment may reinforce regeneration by increasing neurotrophin production and survival of transplanted cells in injured spinal cords. ChinaSCINet is conducting several clinical trials testing lithium and umbilical cord blood cell transplants to treat spinal cord injury.
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Discusses the types of stem cells for spinal cord injury treatment, highlighting advantages and disadvantages.
Reports on preclinical research showing effectiveness of umbilical cord blood cells in spinal cord injury models.
Describes ongoing clinical applications of UCB cells in spinal cord injury and other conditions.
Investigates lithium's effects on enhancing neuronal regeneration and its combined therapeutic potential.
Demonstrates increased survival and proliferation of N01.1 cells in spinal cord injury models with lithium.
Summarizes recent studies on lithium's impact on neurotrophin production and its role in ALS treatment.
Outlines the phases of various trials regarding lithium and cell transplantation for spinal cord injury.
Details surgical approaches and rehabilitation results from a case study on spinal cord injury patients.
Presents recovery data using Kunming Locomotor Scale, demonstrating improvements post-surgery and rehabilitation.
Proposes conducting clinical trials for evaluating cell transplantation safety and efficacy in spinal injuries.
Concludes with insights into the potential and readiness of therapies for clinical application in spinal cord injury.
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