Batch of One
Batch of One
Leo Barella
Chief Technology Officer - Takeda
A batch of one
A batch of one
A batch of one
Genome
Transcriptome
Proteome
Phenotype Environment
(Diet, Age,
Lifestyle, Drug,
Disease)
What
could
happen
What
might
happen
What
is
happening
AI has broad utility across a number of use case
LIFE SCIENCES
• Disease Understanding
• Drug Repurposing
• Drug Discovery
PAYORS
• Risk Stratification
• Patient Engagement
• Customer Service
CARE DELIVERY
• Care Management Plans
• Treatment Selection
• Remote Monitoring
CONSUMER
• Nutrition
• Care Management
• Wellness
Life Sciences
REDEFINING BIOLOGICAL
UNDERSTANDING OF
DISEASE
The integration of clinical data, millions of
chemical profiles, in-vivo assay and AI
drives target discovery, generating more
effective leads at scale
DISEASE UNDERSTANDING
Breaking down biochemical processes and
physiology to better map natural history of
health, disease and the diagnostic process
specifically analyzing the interaction with
the individual patient
DRUG REPURPOSING
Mapping relationships between known
drugs to novel indications by creatively
leveraging compound libraries
DRUG DISCOVERY
With an understanding of structural biology
creating new classes of drug categories and
interventions.
It is more important to know what sort of
person has a disease than to know what
sort of disease a person has.
Hippocrates (460 b.c. - 375 b.c.)
Payors
RETHINKING RISK STRATIFICATION &
POPULATION HEALTH
Payors are aiming to strike a balance
between broad population coverage and
meeting members expectations on how
they
interact with technology. Further AI
approaches can help facilitate value based
reimbursement strategies
RISK STRATIFICATION
Applied analytics to predict patient
outcomes and inform treatment
recommendations
PATIENT ENGAGAMENT
Machine learning to tailor member outreach
based on clinical, claims and contextual
data
CUSTOMER SERVICE
Virtual agents to help members navigate
their benefits quickly and efficiently
Care Delivery
Gaining 360º view of
patient need
Care delivery can be viewed as a complex
process with many interdependencies.
AI approaches can help streamline the
delivery of care and how clinical insights
are discovered
CARE MANAGEMENT PLAN
Optimizing care management and creating
guidelines to manage follow-ups, intakes ,
readmissions and more
TREATMENT SELECTION
Identifying methods to provide better
treatments, early switch rates and improve
adherence
REMOTE MONITORING
Medical or Consumer grade sensors and
clinical algorithms track high risk patients
beyond facility walls
CONSUMER
Novel interfaces and
visual experiences
Consumer facing applications of AI are
emerging across every major health
segment.
Advancements in natural language
processing
(NLP), sensors, voice recognition,
augmented
reality (AR), sentiment analysis, and more
are
raising the sophistication of digital
interaction
and reshaping the consumer experience
NUTRITION
Virtual agents, food image analysis and
personalized nutrition based on
microbiome
and other biological determinants
CARE MANAGEMENT
Enabling personalized medicine, based on
the
use of genomics and research models
NOVEL EXPERIENCES
Interactive technology and new engagement
models via robotics

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A batch of one

  • 1. Batch of One Batch of One Leo Barella Chief Technology Officer - Takeda
  • 5. Genome Transcriptome Proteome Phenotype Environment (Diet, Age, Lifestyle, Drug, Disease) What could happen What might happen What is happening
  • 6. AI has broad utility across a number of use case LIFE SCIENCES • Disease Understanding • Drug Repurposing • Drug Discovery PAYORS • Risk Stratification • Patient Engagement • Customer Service CARE DELIVERY • Care Management Plans • Treatment Selection • Remote Monitoring CONSUMER • Nutrition • Care Management • Wellness
  • 7. Life Sciences REDEFINING BIOLOGICAL UNDERSTANDING OF DISEASE The integration of clinical data, millions of chemical profiles, in-vivo assay and AI drives target discovery, generating more effective leads at scale DISEASE UNDERSTANDING Breaking down biochemical processes and physiology to better map natural history of health, disease and the diagnostic process specifically analyzing the interaction with the individual patient DRUG REPURPOSING Mapping relationships between known drugs to novel indications by creatively leveraging compound libraries DRUG DISCOVERY With an understanding of structural biology creating new classes of drug categories and interventions. It is more important to know what sort of person has a disease than to know what sort of disease a person has. Hippocrates (460 b.c. - 375 b.c.)
  • 8. Payors RETHINKING RISK STRATIFICATION & POPULATION HEALTH Payors are aiming to strike a balance between broad population coverage and meeting members expectations on how they interact with technology. Further AI approaches can help facilitate value based reimbursement strategies RISK STRATIFICATION Applied analytics to predict patient outcomes and inform treatment recommendations PATIENT ENGAGAMENT Machine learning to tailor member outreach based on clinical, claims and contextual data CUSTOMER SERVICE Virtual agents to help members navigate their benefits quickly and efficiently
  • 9. Care Delivery Gaining 360º view of patient need Care delivery can be viewed as a complex process with many interdependencies. AI approaches can help streamline the delivery of care and how clinical insights are discovered CARE MANAGEMENT PLAN Optimizing care management and creating guidelines to manage follow-ups, intakes , readmissions and more TREATMENT SELECTION Identifying methods to provide better treatments, early switch rates and improve adherence REMOTE MONITORING Medical or Consumer grade sensors and clinical algorithms track high risk patients beyond facility walls
  • 10. CONSUMER Novel interfaces and visual experiences Consumer facing applications of AI are emerging across every major health segment. Advancements in natural language processing (NLP), sensors, voice recognition, augmented reality (AR), sentiment analysis, and more are raising the sophistication of digital interaction and reshaping the consumer experience NUTRITION Virtual agents, food image analysis and personalized nutrition based on microbiome and other biological determinants CARE MANAGEMENT Enabling personalized medicine, based on the use of genomics and research models NOVEL EXPERIENCES Interactive technology and new engagement models via robotics