End-to-end (E2E) testing is a comprehensive approach in mobile app development that evaluates the performance and functionality of an application by simulating real-world user interactions from start to finish. It aims to ensure seamless integration between components such as databases, servers, and user interfaces while providing insights into user experience. The document discusses various E2E testing methods, the importance of test automation, best practices, challenges, and highlights specific tools like Testrigor, Mabl, and Autify.