This document describes a study that uses a hybrid genetic algorithm-TOPSIS (HGTS) approach to determine the optimal operator assignment in cellular manufacturing systems. The HGTS approach considers attributes like number of operators, lead time, waiting time, completed parts, operator utilization, and machine utilization to evaluate alternative assignment scenarios. Computer simulation is used to obtain attribute values for each scenario. HGTS aims to find the scenario with the shortest distance to an ideal scenario and farthest from a negative-ideal scenario. The proposed HGTS approach is shown to provide superior results compared to other multi-criteria decision making techniques like TOPSIS, DEA, and PCA.