Adrenalin

Adrenalin

• 1.
  ADRENALIN JOHNY WILBERT, M.SC[N] LECTURER, APOLLOINSTITUTE OF HOSPITAL MANAGEMENT AND ALLIED SCIENCE
• 2.
  Mechanism of action Theaction of adrenalin may vary by the type of tissue it act,  It causes smooth muscle relaxation in the airway It causes smooth muscle contraction in the arterioles In cardiac muscles increase contractability
• 3.
  INDICATION: • Anaphylaxis reaction •Hypotension • Bronchospasm • Cardiac arrest • Asystole
• 4.
  • DOSE: For Infusion: 0.05 – 0.1 microgram/kg/minute maximum dose: 1 – 1.5 microgram/kg/minute For In arrest : 1 ml every 2 minutes
• 5.
  • Dilution • 1ampule =1ml/1mg • Prepration : 4ml of adrenalin + 46 ml NS =50 ml • Drug concentration = 4mg/50ml =0.8mg • 0.8mg x 1000 = 80 mcg/ml • Rate of infusion : desired dose x 60 =ml/hr 80 mcg Example : 2 mcg x 60 min = 1.5 80
• 6.
  Drug interaction • Interactswith β-blocking agents, digitalis glycosides, antidepressants,
• 7.
  ADVERSE EFFECTS: • Hypertension •tachycardia • Extravasations • Anxiety, dysrhythmias • dizziness • pallor • tremor, • insomnia • Headache, nausea • palpitations
• 8.
  Nursing consideration: • Inotropesmust be adminstered in central line • Do not cease infusion abruptly, • Should be used with caution in patients with atherosclerosis, mesentric and peripheral vascular thrombosis or other occlusive vascular diseases, metabolic acidosis, hypoxia or hyperthyroidism. • It should be avoided in patients who are hypersensitive to the drug. • discard diluted solutions after 24 hours Protect ampoules from light during storage and discard if discoloured
• 9.
  • Follow tenrights • Monitor for adverse effect • Continuous BP using invasive arterial BP monitor • connect the patient with cardiac monitor and monitor ECG rythym • Inotropes must be administered using infusion or syringe • Should follow standard dilution • The lable on loaded drug should contain drug concentration and dilution • Monitor urine output
• 10.
  THANK YOU