The skin has three main layers - the epidermis, dermis and subcutaneous tissue. The epidermis is the outermost layer and contains no blood vessels. It has multiple layers that cells move through as they are replaced every 28 days. The dermis lies below and contains collagen, elastin and blood vessels that provide structure and nourishment. It has two layers - a papillary layer with nerve endings and a reticular layer with hair follicles and glands. The deepest layer, subcutaneous tissue, contains fat and connects the dermis to underlying structures. Together these layers contain millions of cells, yards of blood vessels and nerves, and various sensory receptors and appendages like hair and glands.