AP PGECET Pharmacy 2018 Syllabus
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This document provides an overview of the topics covered in the APPGECET-2018 exam for the Pharmacy program. The exam will test knowledge in several areas including: 1) Pharmacognosy & Phytochemistry which involves the study and identification of crude drugs, phytoconstituents, and plant tissue culture. 2) Pharmaceutical Chemistry covering topics like drug design, stereochemistry, classification of various drug categories, and their synthesis, structure-activity relationships, and metabolism. 3) Pharmaceutics involving physical pharmacy concepts, pharmaceutical technology, formulation and evaluation of different dosage forms, biopharmaceutics, and pharmacokinetics. 4) Pharmacology covering general principles and the pharmac
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AP PGECET Pharmacy 2018 Syllabus
- 1. APPGECET-2018 Pharmacy (PY) Pharmacognosy & Phytochemistry: Sources of crude drugs of natural origin and their classification; Factors affecting the cultivation of medicinal and aromatic plants, plant growth regulators; Adulteration and types of adulterants; Methods of evaluation of crude drugs; Definition, classification, properties, general method of extraction, chemistry, tests for detection of following classes of phytoconstituents- Alkaloids, Glycosides, Terpenoids (volatile oils, resin and resin combinations), Tannins, Carbohydrates, Lipids, Proteins and Enzymes. Pharmacognostic aspects of crude drugs containing aforesaid classes of phytoconstituents covering their biological source, diagnostic features, chemical constituents, tests for identification, uses, adulterants, substituents and allied drugs (if any); Study of fibres used in pharmacy- Cotton, Silk, Wool, Nylon, Polyesters, Glasswool and Asbestos. Plant tissue culture: Types of cultures, nutritional requirements, growth and their maintenance. Applications of plant tissue culture. Pharmaceutical Chemistry: Introduction to drug design. Stereochemistry of drug molecules.Structure, nomenclature, classification, synthesis, SAR and metabolism of the following category of drugs, which are official in Indian Pharmacopoeia and British Pharmacopoeia. Hypnotics and Sedatives, Neuroleptics, Antidepressants, Anxiolytics, Anticonvulsants, Local Anaesthetics; Cardiovascular drugs- Antianginal agents Vasodilators, Adrenergic and Cholinergic drugs, Cardiotonic agents, Diuretics, Antihypertensive drugs, Antilipedmic agents; Antihistaminics; Analgesics; NSAIDS; Hypoglycemic agents; Anticoagulants; Antiplatelet agents. Chemotherapeutic agents- Antibiotics, Antibacterials, Antifungal, Antiviral, Antimalarial, Anticancer and Antiamoebic drugs. Inorganic pharmaceuticals: Gastrointestinal agents; Electrolytes; Haematinics; Topical agents; Dental products; limit tests for Arsenic, Iron, Lead, Barium, Chloride and Sulphate. Pharmaceutics: Physical pharmacy: Matter and properties of matter; Micromeretics and powder rheology; Surface and interfacial phenomenon; Viscosity and rheology; Dispersion systems; Complexation; Kinetics and drug Stability. Pharmaceutical Technology: Preformulation studies; Pharmaceutical calculations; Formulation,development, packaging and evaluation of: liquid dosage forms, semisolid dosage forms, tablets, capsules, micro-encapsulation, aerosols, parenteral products, ophthalmic preparations, suppositories, blood products and plasma substitutes and surgical products; Cosmetic preparations: Skin, Hair, Nails, Lips, Eye, Baby care products and Dentifrices. 1
- 2. APPGECET-2018 Biopharmaceutics & Pharmacokinetics: Passage of drugs across biological barrier; Factors influencing absorption- biological, physico-chemical, physiological and pharmaceutical; Basic principles of Pharmacokinetics; Compartment kinetics- One compartment model with reference to Intravascular and oral drug administration; Concept of clearance; Non-linear pharmacokinetics with reference to one compartment model after I.V. drug administration; Bioavailability and bioequivalence. Pharmacology: General pharmacological principles including Toxicology; Pharmacology of drugs acting on Central nervous system, Cardiovascular system (including diuretics), Autonomic nervous system, Gastro intestinal system and Respiratory system; Pharmacology of Autacoids: Histamine, Antihistaminic drugs. 5-HT- its agonists and antagonists, Prostaglandins, Thromboxanes, and Leucotrienes. Steroidal and Nonsteroidal Anti-inflammatory Drugs. Pharmacology of Endocrine system: Thyroid hormones and Antithyroid drugs; Insulin; Oral hypoglycemics; Estrogens; Progesterone and Oral contraceptives; Androgens and Anabolic steroids; Chemotherapeutic agents; Bioassays, Immuno Pharmacology. Drugs acting on the Blood and Blood forming organs. Clinical Pharmacy: Therapeutic Drug Monitoring, Dosage regimen in Renal and Hepatitic impairment. Drug-Drug interactions and Drug-food interactions, Adverse Drug reactions. Medication History, interview and Patient counseling Pharmaceutical Analysis and Quality Assurance: Concepts of qualitative and quantitative analysis, fundamentals of volumetric analysis, methods-of expressing concentration, primary and secondary standards; acid-base, oxidation-reduction, precipitation, non-aqueous and complexometric titrations; gravimetric analysis; concept of error, precision, accuracy, specificity, sensitivity, detection limit, linearity and range. Ruggedness, standards, standardization, calibration of analytical equipments. Principles, instrumentation and applications of the following: Absorption spectroscopy (UV, visible & IR), Fluorimetry, Flame photometry, Potentiometry, Conductometry and Polarography; Chromatographic methods (Paper, TLC, Column, GC and HPLC); Pharmacopoeial assays. Quality assurance and quality control methods, concepts of GMP and GLP. Forensic pharmacy: Pharmacy Act 1948; Drugs and Cosmetics Act 1940 and Rules 1945 and amendments thereto; Narcotic Drugs & Psychotropic Substances Act 1985 and Rules; Drugs Price Control Order. 2