This document introduces two volumes on applications of human-computer interaction (HCI) research in management information systems (MIS). The first volume covers HCI concepts and theories, while this second volume focuses on applications, case studies, and specific contexts. Some areas covered include electronic commerce, collaboration, culture/globalization, training/learning, system development processes, healthcare, and research methodology. The introduction provides context on the interdisciplinary nature of HCI research and its practical applications across many fields.