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Azithromycin
- 1. P O WE R E D B Y , P O O J I T H A M O D E P A L L I AZITHROMYCIN
- 2. Generic name :azithromycin Brand name : azasite ,azithromycin 3 day dose pack , azithromycin 5 day dose pack , zithromax , zithromax TRI-PAK , zithromax Z - PAK , Z max Drug class : macrolides
- 3. WHAT IS AZITHROMYCIN? Azithromycin is an antibiotic Azithromycin is used to treat different types of infections caused by the bacteria , such as respiratory infections , skin infections , ear infections, eye infections and sexually transmitted diseases Azithromycin may also be used for purposes not listed in medical guide Mech of action – inhibit RNA dependent protein synthesis
- 4. PHARMACOKINETICS Route ofadministration – oral Bioavailability – approximately 37 % Metabolism – hepatic Excretion – biliary Drug elimination is biphasic with Half life – 5 days DOSE- 500mg a day for 3-10 days
- 5. SIDE EFFECTS MOST COMMONEFFECTS Nausea ,Vomiting , Diarrhea ,Pain in abdomen LESS COMMON EFFECTS Heart palpitations , acid reflux , dizziness , headache, fatigue , vaginitis,skin rashes SERIOUS EFFECTS Liver damage( in liver patients) , heart rhythm changes ( people who take heart medications and low blood potassium) , serious allergic conditions
- 6. DRUG INTERACTIONS There are327 drugs which interact with azithromycin categorized as 71 major , 235 moderate and 21 minor interactions (you can check all these interactions in the website https://www.drugs.com ) Most common interactions are nelfinavir , warfarin, digoxin , colchicine , phenytoin , antacids that contain magnesium or alluminium
- 7. CONTRA INDICATIONS andTHERAPEUTIC USES Contraindicated in patients with known hypersensitivity to azithromycin , or any other macrolide and in hepatic diseases. Use with caution in renal failure Therapeutic uses of azithromycin is bronchitis , pneumonia , std , lungs , sinuses , skin, throat and reproductive organs
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