This document provides an overview of biomedical instrumentation. It discusses how instrumentation is used to monitor and control process variables for measurement and control. Biomedical instrumentation specifically creates instruments to measure, record, and transmit data to and from the body. Some key types of biomedical instrumentation systems are direct/indirect, invasive/noninvasive, contact/remote for sensing and actuating in real-time or statically. Several important instruments are discussed in detail, including X-rays, electrocardiography, magnetic resonance imaging, ultrasound, and computed tomography. The document outlines the basic workings, advantages, and disadvantages of these key biomedical instruments.