Mark Dunphy discusses the evolution of the Activity Feed system at Behance from MongoDB to Cassandra. The initial MongoDB implementation worked well for the smaller user base in 2011 but struggled with node failures, disk fragmentation, and downtime as the system scaled. Cassandra was chosen to replace it due to its scalability, performance, and ease of maintenance. Dunphy details the process of learning Cassandra, modeling the data, and developing a strategy for writes and reads that allowed the system to handle thousands of writes and reads per second while serving the Activity Feed to users.