Lars Juhl Jensen
Cellular Network Biology
Large-scale integration of data and
text
community resources
text mining
Cytoscape App
software demo
community resources
STRING
protein networks
string-db.org
curated knowledge
Letunic & Bork, Trends in Biochemical Sciences, 2008
genomic context
experimental data
von Mering et al., Nucleic Acids Research, 2005
calibrated quality scores
von Mering et al., Nucleic Acids Research, 2005
RAIN
ncRNA networks
Junge, Refsgaard & Garde et al., Database, 2017
STITCH
chemical networks
Kuhn et al., Nucleic Acids Research, 2016stitch-db.org
drug databases
high-throughput screens
COMPARTMENTS
subcellular localization
Binder et al., Database, 2014compartments.jensenlab.org
GO annotations
sequence-based prediction
TISSUES
tissue expression
tissues.jensenlab.org
Santos et al., PeerJ, 2015
Palasca & Santos et al., submitted, 2017
expression atlases
Palasca & Santos et al., submitted, 2017
Human HPA RNA−seq
Human RNA−seq atlas
Human GNF
Human Exon Array
Pig RNA−seq WUR
Pig RNA−seq Aarhus
Pig Array
Rat RNA−seq BodyMap
Rat RNA−seq MIT
Rat Array
Mouse RNA−seq MIT
Mouse RNA−seq Encode
Mouse GNF V3
Mouse GNF
Heart
Intestine
Kidney
Liver
Nervoussystem
Muscle
Lung
Spleen
Lymphnode
Pancreas
Skin
Stomach
Thyroidgland
Bonemarrow
Saliva
Adrenalgland
Urine
Blood
Eye
Gallbladder
Bone
MouseRatPigHuman
DISEASES
disease associations
diseases.jensenlab.org Frankild et al., Methods, 2015
curated knowledge
missing most of the data
text mining
>10 km
too much to read
computer
as smart as a dog
teach it specific tricks
named entity recognition
dictionary
genes/proteins
chemicals
cellular compartments
tissues
diseases
synonyms
cyclin dependent kinase 1
CDC2
orthographic variation
cyclin dependent kinase 1
cyclin-dependent kinase 1
CDC2
hCdc2
“black list”
SDS
co-mentioning
scoring scheme
open source
highly efficient
broadly applicable
Cytoscape
networks
tables
visual styles
stringApp
import from STRING
protein query
PubMed query
disease query
subcellular localization
tissue expression
enrichment analysis
Thank you
STRING & STITCH
Damian Szklarczyk
Nadezhda Donche
va
John
"Scooter" Morris
Helen Cook
Michael Kuhn
Stefan Wyder
Milan Simonovic
Alexander Roth
Peer Bork
Christian von Merin
g
COMPARTMENTS,
TISSUES &
DISEASES
Alberto Santos
Oana Palasca
Sune Pletscher-
Frankild
Christian Stolte
Janos Binder
Kalliopi Tsafou
Jan Gorodkin
Sean I. O’Donoghue
RAIN
Alexander Junge
Jan C. Refsgaard
Christian Garde
Xiaoyong Pan
Alberto Santos
Ferhat Alkan
Christian Anthon
Christian von Meri
ng
Christopher
Workman
Jan Gorodkin

Cellular Network Biology: Large-scale integration of data and text