CELLULITIS 
Dr. vijay dihora
DEFINITION 
 An acute, diffuse, spreading infection of the 
skin, involving the deeper layers of the skin and 
the subcutaneous tissue. 
 Periorbital cellulitis is a special form of cellulitis 
that usually occurs in children. In this form of 
cellulitis, unilateral swelling and redness of the 
eyelid and orbital area, as well as fever and 
malaise are usually present.
Serious infections of deeper skin structures
CAUSES 
 Staphylococcus 
 Streptococcus Group A β 
 H. Influenzae (periorbital cellulitis) 
 pasteurella multocida 
 Facial cellulitis in children < 3 years old 
Hemophilus influenzae or Streptococcus 
pneumoniae
PREDISPOSING RISK FACTORS 
 Local trauma (e.g., lacerations, insect bites, 
wounds, shaving) 
 Skin infections such as impetigo, scabies, furuncle, 
tinea pedis 
 Underlying skin ulcer 
 Fragile skin 
 Immunocompromised host 
 Diabetes mellitus 
 Inflammation (e.g., eczema) 
 Edema secondary to venous insufficiency or 
lymphedema
TYPICAL FINDINGS OF 
CELLULITIS 
History 
 Presence of predisposing risk factor 
 Area increasingly red, warm to touch, painful 
 Area around skin lesion also tender but pain 
localized 
 Edema 
 Mild systemic symptoms – low-grade fever, chills, 
malaise, and headache may be present
Physical Assessment 
 Local symptoms: 
 Erythema and edema of area 
 Warm to touch, 
 Possibly fluctuant (tense, firm to palpation) 
 May resemble peau d’orange 
 Advancing edge of lesion diffuse, not sharply 
demarcated 
 Small amount of purulent discharge may be 
present 
 Unilateral
Systemic indications: 
 Increased temperature 
 Increased pulse 
 Lymphadenopathy of regional lymph nodes and / 
or lymphangitis
Diagnostic Tests 
 Swab any wound discharge for culture and 
sensitivity
MANAGEMENT AND 
INTERVENTIONS 
 Do not underestimate cellulitis. It can spread very 
quickly and may progress rapidly to necrotizing 
fasciitis. It should be treated aggressively and 
monitored on an ongoing basis
Goals of Treatment for Mild 
Cellulitis 
 Resolve infection 
 Identify formation of abscess 
 Check tetanus prophylaxis
Non-pharmacologic 
Interventions 
 Apply warm or, if more comfortable, cool saline 
compresses to affected areas qid for 15 minutes. 
 Mark border of erythema with pen to monitor 
spread. 
 Elevate, rest and gently splint the affected limb.
Pharmacologic Interventions 
Pain management: 
 acetaminophen 10-15mg/kg per day po q4-6hours. 
Do not exceed 75mg/kg per 24 hours 
 Oral antibiotics if no known MRSA or non-purulent 
cellulitis: 
cephalexin 40mg/kg per day po divided qid for 7-10 
days uUsually first choice due to taste), or 
cloxacillin 40mg/kg per day po divided qid for 7-10 
days 
 Patients with penicillin allergy: 
erythromycin 40 mg/kg/day divided bid for 7-10 
days 
 Patients with known community acquired MRSA or 
purulent cellulitis: 
trimethoprim-sulfamethoxazole 8-12 mg / kg per day 
po bid for 7 days (dosing is based on trimethoprim)
Pregnant or Breastfeeding Women 
 Cephalexin, cloxacillin, erythromycin and 
acetaminophen may be used as listed above. 
 Trimethoprim-sulfamethoxazole is contraindicated

Cellulitis

  • 1.
  • 2.
    DEFINITION  Anacute, diffuse, spreading infection of the skin, involving the deeper layers of the skin and the subcutaneous tissue.  Periorbital cellulitis is a special form of cellulitis that usually occurs in children. In this form of cellulitis, unilateral swelling and redness of the eyelid and orbital area, as well as fever and malaise are usually present.
  • 3.
    Serious infections ofdeeper skin structures
  • 4.
    CAUSES  Staphylococcus  Streptococcus Group A β  H. Influenzae (periorbital cellulitis)  pasteurella multocida  Facial cellulitis in children < 3 years old Hemophilus influenzae or Streptococcus pneumoniae
  • 6.
    PREDISPOSING RISK FACTORS  Local trauma (e.g., lacerations, insect bites, wounds, shaving)  Skin infections such as impetigo, scabies, furuncle, tinea pedis  Underlying skin ulcer  Fragile skin  Immunocompromised host  Diabetes mellitus  Inflammation (e.g., eczema)  Edema secondary to venous insufficiency or lymphedema
  • 7.
    TYPICAL FINDINGS OF CELLULITIS History  Presence of predisposing risk factor  Area increasingly red, warm to touch, painful  Area around skin lesion also tender but pain localized  Edema  Mild systemic symptoms – low-grade fever, chills, malaise, and headache may be present
  • 8.
    Physical Assessment Local symptoms:  Erythema and edema of area  Warm to touch,  Possibly fluctuant (tense, firm to palpation)  May resemble peau d’orange  Advancing edge of lesion diffuse, not sharply demarcated  Small amount of purulent discharge may be present  Unilateral
  • 9.
    Systemic indications: Increased temperature  Increased pulse  Lymphadenopathy of regional lymph nodes and / or lymphangitis
  • 11.
    Diagnostic Tests Swab any wound discharge for culture and sensitivity
  • 12.
    MANAGEMENT AND INTERVENTIONS  Do not underestimate cellulitis. It can spread very quickly and may progress rapidly to necrotizing fasciitis. It should be treated aggressively and monitored on an ongoing basis
  • 13.
    Goals of Treatmentfor Mild Cellulitis  Resolve infection  Identify formation of abscess  Check tetanus prophylaxis
  • 14.
    Non-pharmacologic Interventions Apply warm or, if more comfortable, cool saline compresses to affected areas qid for 15 minutes.  Mark border of erythema with pen to monitor spread.  Elevate, rest and gently splint the affected limb.
  • 15.
    Pharmacologic Interventions Painmanagement:  acetaminophen 10-15mg/kg per day po q4-6hours. Do not exceed 75mg/kg per 24 hours  Oral antibiotics if no known MRSA or non-purulent cellulitis: cephalexin 40mg/kg per day po divided qid for 7-10 days uUsually first choice due to taste), or cloxacillin 40mg/kg per day po divided qid for 7-10 days  Patients with penicillin allergy: erythromycin 40 mg/kg/day divided bid for 7-10 days  Patients with known community acquired MRSA or purulent cellulitis: trimethoprim-sulfamethoxazole 8-12 mg / kg per day po bid for 7 days (dosing is based on trimethoprim)
  • 16.
    Pregnant or BreastfeedingWomen  Cephalexin, cloxacillin, erythromycin and acetaminophen may be used as listed above.  Trimethoprim-sulfamethoxazole is contraindicated