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Cholesterol new
- 1. SYNTHESIS & DEGRADATION OF CHOLESTEROL By Dr.M. ANUSWARU , 3RD YEAR POST GRADUATE
- 2. • IN GREEK‘CHOLE’ MEANS BILE • ‘ STEROS ‘ MEANS SOLID. • AS IT IS FIRST ISOLATED FROM BILE JUICE IT IS NAMED AS CHOLESTEROL. • IT IS EXCLUSIVELY ANIMAL STEROL • MOLECULAR FORMULA IS C27 H45OH.
- 4. ⚫ All steroidshave cyclopentanoperhydrophenanthrene ring system. ⚫ Cholesterol is amphipathic in nature. ⚫ It possesses both hydrophilic & hydrophobic regions in the structure. ⚫ All carbon atoms of cholesterol are derived from acetyl CoA.
- 5. ⚫ Total 27carbon atoms. ⚫ One hydroxyl group at 3rd position which is characteristic of all sterols. ⚫ The OH group is β-oriented, projecting above the plane of ring. ⚫ Double bond between carbon atoms 5& 6. ⚫ An eight carbon side chain, β-oriented, attached to 17th carbon.
- 9. Biosynthesis of Cholesterol About1gm of cholesterol is synthesized per day in adults. Almost all tissues of the body participate in the cholesterolsynthesis. Small Portion of it Synthesized in Arteial wall. The largest contribution is made by...... ).> LIVER{50%), ).> INTES TINE( 15%), ).> SKIN ).>ADRENAL CORTEX, • •
- 10. SITE OF CHOLESTEROLSYNTHESIS MAJOR SITE OF SYNTHESIS IS • LIVER • INTESTINES • SKIN • ADRENAL CORTEX • GONADS (OVARIES & TESTIS)
- 11. ⚫ Synthesis ofHMG CoA (β-hydroxy β- methyl glutaryl CoA ) ⚫ Formation of Mevalonate ⚫ Production of isoprenoid units ⚫ Synthesis of squalene ⚫ Conversion of squalene to cholesterol. Steps of synthesis of cholesterol
- 12. FOR SYNTHESIS OFONE MOLECULE OF CHOLESTEROL 18 ACETYL CO A 36 ATP 16 NADPH ARE REQUIRED.
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