This study compared different soil tillage systems and crop rotations for wheat production in Turkey's Central Anatolian Plateau region. The objectives were to evaluate the effects of tillage and previous crops on wheat yield under both irrigated and rainfed conditions. Field experiments from 2002-2007 compared conventional tillage, reduced tillage, and no-till under various crop rotations. The results showed that under rainfed conditions, no-till produced the highest wheat yields. Under irrigated conditions, reduced tillage and no-till with sugar beet or bean crop rotations produced the highest wheat yields. Adopting alternative tillage practices and crop rotations could improve wheat yields and farm profits in the region.