Download to read offline
Uploaded byColumbia Pain Management, PC
CPM_Regen_Med_2_Linked_in
Regenerative medicine focuses on replacing or regenerating human cells, tissues, or organs to restore or establish normal function. Techniques include prolotherapy, platelet rich plasma, platelet lysate, and adult stem cells harvested from bone marrow or adipose tissue. These techniques aim to promote the body's natural healing abilities through growth factors and stem cells to repair damaged or diseased cells and tissues.
CPM_Regen_Med_2_Linked_in
- 1. David P. Russo,DO Board Certified Physical Medicine & Rehabilitation Board Certified Pain Medicine Hood River Oregon Regenerative Medicine Basics
- 3.
- 4. Regenerative Medicine • TheTheory – The process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects • The Practice – The application of scientific principles and medical technology to support, augment or induce tissue healing or growth.
- 5. Regenerative Medicine ToolKit • Diet, nutrition, life-style • Exercise • Prolotherapy • Platelet Rich Plasma • Platelet lysate • Stem cells
- 6. Diet, Nutrition, Lifestyle Avoid“toxins…” • Tobacco and nicotine • Illicit drugs • Too much alcohol • Too much coffee • Too much red meat • High sugar/processed food • Fried food/poly-unsaturated fats • Certain medications – NSAIDS, statins, ACE-inhibitors, others Be “friends” with… • …other people • Daily activity and exercise • Adequate sleep • Meditation/contemplation • Vegetables, fiber, whole foods • Garlic, ginger, natural B- vitamin sources, anti-oxidants • Certain supplements – Fish oils, Curcumin, glucosamine, Vitamin D, others
- 7. Exercise Exercise is medicine… •PROVEN effects – Tissue health, healing, and viability – Longevity – Reduced disease burden – Reduced disability – Improved emotional and psychological functioning “Motion is lotion!” A cornerstone of both Rehabilitation and Regenerative Medicine is coaching and encouraging our patients to be active, flexible, strong, and coordinated; prescribing and monitoring their progress toward better overall fitness.
- 8. Prolotherapy • Dry needling(debridement) • Injection of irritative substance to “proliferate” tissue healing. – Dextrose 12.5% – Glycerin – Sodium Morrhuate • Target of therapy is the “enthesis” – Soft tissue attachment site to bone The ENTHESIS
- 10. Platelets? • Platelets containgranules that store large numbers of “growth factors” • Alpha granules released (activated) when platelets aggregate and adhere to a site of injury or inflammation • These growth factors include: interleukin-1, tumor necrosis factor, transforming growth factor, insulin growth factor and more • It is the activation of platelets and release of the various growth factors that makes them special and is the key to enhancing tissue repair and healing!
- 11.
- 12.
- 13.
- 14. • Platelet PlasmaPlasma (PRP) – PRP is simply whole blood that is centrifuged to create an increased concentration of platelets with or without WBC’s • Mechanically or manually – Manual processing allows for better concentration Platelet Rich Plasma
- 15. Platelet Rich Plasma Mechanicalprocessing Manual processing
- 16.
- 18.
- 19. Platelet Lysate **Promotes tissuegrowth and healing with less inflammation than PRP**
- 21. Stem Cell Basics •Undifferentiated cells capable of turning into different kinds of tissue • Three types: – Embryonic—pluripotent (can be anything) – Adult/constituent—multipotent (can be become some things); differentiated by tissue milieu – iPSC—lab cultured cells “forced” by genetic tinkering into becoming a particular tissue • Autologous-from the same person • Allogenic-from different people
- 22. Adult Stem Cells •Present in bone marrow and adipose tissue • Three types – hematopoetic stem cells form red and white blood cells – Stromal or mesenchymal form skeletal tissue – Neural stem cells form neural elements • They respond to tissue damage signals and initiate repair
- 23. Bone Marrow Aspiration •Bone marrow is harvested from the patient’s illiac crest • Manually processed to isolated the stem cell enriched fraction • Re-injected into the patient under image guidance
- 24.
- 26.
- 27. Summary • Regenerative Medicineis an approach to tissue healing that focuses on host factors first. • Many of the techniques of Regenerative Medicine emulate things we already do. • Biologics (PRP, PL, SC) are not covered by insurance • Patient education and selection are critical to the success of Regenerative Medicine procedures