The presentation by Norberto Leite focuses on the differences in data modeling for MongoDB compared to relational databases, emphasizing a flexible methodology that incorporates workload description, relationship identification, and schema design patterns. Key points include the importance of understanding document structures like polymorphism and sub-documents, as well as practical applications in case studies such as a coffee shop franchise management system. The presentation also highlights considerations for schema evolution, indexing, and the implementation of transactions in MongoDB.