This document is the dissertation of Alexandros Sklavos submitted to Technische Universitat Kaiserslautern for the degree of Doctor of Engineering. The dissertation proposes a service area based OFDM air interface for beyond 3G mobile radio systems. It introduces the demands on future mobile radio systems, compares service area and cellular architectures, describes the OFDM transmission technique, reviews the state of the art, and outlines the structure of the thesis. The dissertation then models OFDM-based MIMO systems, proposes uplink and downlink transmission schemes in the service area concept, and investigates their performance through simulation.