DIURETICS How Do They Work

Diuretics work by inhibiting sodium reabsorption in the kidneys, which leads to increased sodium and water excretion in the urine. There are three main types of diuretics: loop diuretics that inhibit the Na-K-2Cl symporter; thiazide diuretics that inhibit the Na-Cl symporter; and mineralocorticoid receptor antagonists that block aldosterone's effects and include spironolactone and eplerenone. Diuretics are used to treat fluid retention, high blood pressure, and other conditions.