Domino is presented as a superior alternative to upgrading an existing Microsoft Exchange infrastructure. It offers more collaborative applications, reliable performance through clustering and failover support, and multi-platform support compared to Exchange 2000 which only runs on Windows 2000. Migrating to Domino is described as easier than upgrading to Exchange 2000 due to tools that simplify the migration process. Key benefits of Domino include reliable architecture, support for more operating systems and clients, and lower costs of ownership versus Exchange 2000.