Drug Discovery - The Origin of New Chemical Entity Pharmaceuticals

The document outlines the drug discovery process, highlighting various approaches and challenges in identifying new chemical entities (NCEs) and active pharmaceutical ingredients (APIs). It emphasizes the importance of biological assays, compound libraries, and regulatory compliance throughout the development phases, as well as the need for innovative strategies to enhance efficacy and reduce side effects. Key issues in drug discovery include target selectivity, therapeutic windows, and the high costs associated with research and development.