E-cigarettes were first patented in 1965 but began appearing in American markets around 2009. They consist of a battery, atomizer, and cartridge containing e-liquid which is typically made up of nicotine, propylene glycol, vegetable glycerin, and flavoring. While e-cigarettes were created as a nicotine delivery system, they can also be used to deliver other drugs. There are concerns about the health impacts of e-liquid ingredients and flavors, as well as risks of accidental poisoning, especially among children. E-cigarette use among youth has increased rapidly in recent years and risks leading them to regular cigarettes. Comprehensive regulation of e-cigarettes is still needed at the federal level.