Original Article
Early ActiveMobilization during Mechanical
Ventilation in the ICU
The TEAM Study Investigators and the ANZICS Clinical Trials Group
N Engl J Med
Volume 387(19):1747-1758
November 10, 2022
2.
Study Overview
• Inthis trial involving patients undergoing mechanical ventilation in the
ICU, an increase in early mobilization did not improve the number of
days alive and out of the hospital.
3.
The TEAM StudyInvestigators and the ANZICS Clinical
Trials Group. N Engl J Med2022;387:1747-1758
4.
Randomization and Outcomes.
TheTEAM Study Investigators and the ANZICS Clinical Trials Group. N Engl
J Med2022;387:1747-1758
5.
Mobilization in theIntensive Care Unit, According to Treatment Group.
The TEAM Study Investigators and the ANZICS Clinical Trials Group. N Engl J
Med2022;387:1747-1758
6.
Characteristics of thePatients at Baseline.
The TEAM Study Investigators and the
ANZICS Clinical Trials Group. N Engl J
Med2022;387:1747-1758
7.
Mobilization in theICU.
The TEAM Study Investigators and the ANZICS Clinical Trials Group. N Engl J
Med2022;387:1747-1758
8.
Primary Outcome, KeySecondary Outcomes, and Adverse Events.
The TEAM Study Investigators and the ANZICS
Clinical Trials Group. N Engl J
Med2022;387:1747-1758
9.
Conclusions
• Among adultsundergoing mechanical ventilation in the ICU, an increase
in early active mobilization did not result in a significantly greater
number of days that patients were alive and out of the hospital than did
the usual level of mobilization in the ICU.
• The intervention was associated with increased adverse events.
#4 Figure 1 Randomization and Outcomes. In this trial involving patients who were undergoing invasive mechanical ventilation, early mobilization included sedation minimization and daily physiotherapy and usual care included the level of mobilization that was normally provided in each intensive care unit (ICU).
#5 Figure 2 Mobilization in the Intensive Care Unit, According to Treatment Group.
#6 Table 1 Characteristics of the Patients at Baseline.