The document presents a new ECG signal compression technique based on discrete wavelet transform (DWT) and QRS-complex estimation. The technique first estimates the QRS-complex from the ECG signal, then subtracts it to form an error signal. This error signal is wavelet transformed, and the coefficients are thresholded based on energy packing efficiency to maximize compression ratio and minimize distortion. Testing on MIT-BIH records showed the technique achieves high compression ratios of 25.15 with low distortion levels of 0.7% PRD.