This document summarizes a study that analyzed the effect of soil-structure interaction on buildings with stiffness irregularities under seismic loads. Finite element models of regular and irregular 11-story buildings founded on hard, medium, and soft soils were created in SAP 2000 software. Response spectrum analysis was performed to compare the time period, base shear, roof displacement, and story drift between regular and irregular buildings. The results showed that for irregular buildings, the time period, displacement, and drift increased while base shear decreased compared to regular buildings. Additionally, the effects were more significant for softer soil conditions. In conclusion, soil flexibility leads to increased seismic response demands for buildings with stiffness irregularities.