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Effect of sympathomimetics on isolated heart of frog
The document discusses the effects of various stimulatory drugs on an isolated heart, specifically focusing on alpha and beta blockers. It outlines different types of alpha blockers (e.g., phentolamine, phenoxybenzamine) and beta blockers (e.g., propranolol, metoprolol), along with their mechanisms of action through sympathomimetics to increase cardiac contractility. Additionally, it provides a procedural approach for stimulating the heart with epinephrine and the effects of beta-1 blockers on this stimulation.
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Effect of sympathomimetics on isolated heart of frog
- 1. Stimulatory drugs on isolatedheart By Dr Sameh AM abdel-ghany
- 3. Alpha blockers • Alpha1 and alpha 2: phentolmaine, phenoxybenzamine and tolazoline. • Alpha 1: prozosin, doxazosin and terazosin. • Alpha 2: yohmbine
- 4. Beta blockers • Beta1,beta2: propranolol • Beta 1: metoprolol and atenolol • Beta 2: butoxamine
- 5. Stimulation of isloatedheart with sympathomimetics To increase cardiac contractilty with Sympathomimetics: Stimulate B1 receptors : e.g • Adrenaline • Noradrenaline • Isoprenaline
- 6. Stimulation of heartwith Epinephrine Steps: 1.Inject Epinephrine produces ↑ in both HR and contractility. 2.Try other B1 stimulants e.g. Norepinephrine and Isoprenaline 3.Inject B1- Blocker e.g Propranolol 4.Inject Epinephrine rapidly before the action of propranolol ends No effect of epinephrine 5.Try other B1 stimulants e.g. Norepinephrine and Isoprenaline after propranolol
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