Efficacy and Potency of drug
- 1. Department of PharmaceuticalDepartment of Pharmaceutical sciencessciences 33rdrd SemesterSemester
- 2. Group membersGroup members Mohammad AsadMohammad Asad Hafiz JunaidHafiz Junaid Amir Sohail KhanAmir Sohail Khan Sana MushtaqSana Mushtaq
- 3. What is Pharmacodynamics Drug response curve EC50 Potency Efficacy Refrences
- 4. Pharmacodynacmics describes the action of drug on body and influence of drug concentration on magnitude of response Most of drugs exerts effect by ineracting with receptor An agent that can bind to recepor and produces iological rsponse is called as agonist
- 5. The interaction between drug and its receptor can be described by a curve called as drug response curve on Vertical axix there is response of drug On horizontal axix there is concentration of dose
- 6. The magnitude of drug effect depends on drug concentration at receptor site and this availbilty and concentration of drug at receptor is determined by both dose of drug administered and by drug pharmacokinetics(ADME)
- 7. When no drug is added then no effect is produced
- 8. When some drug is added then we get response
- 9. By adding more drug we get maximum response
- 10. A time will reach on which adding more drug will not cause increase in response because we have reached to maximum effect
- 11. EC50EC50 Is concentration of drug needed to get half of the maximum effect
- 12. Two important properties of drug can be found by dose reponse curve Efficacy Potency PotencyPotency amount of drug necessary to produce maximum effect is the potecncy of drug
- 13. Candesartan and ibesartan are angiotensin receptor blocker Candesartan is more potent then Ibesartan because the dose range for candesartan is 4 to 32 mg as compared to dose range of ibesartan whose dose range is 25 to 300 mg
- 15. Ability of a drug to elicit a response when it interacts with a receptor Efficacy is dependent on; the number of drug-receptor complexes formed efficiency of the coupling of receptor activation to cellular responses. Maximal efficacy of a drug assumes that all receptors are occupied by the drug and if more drugs are added, no additive response will be observed. Maximal response (efficacy) is more important than drug potency. A drug with greater efficacy is more therapeutically beneficial than the one that is more potent.
- 18. Lipincott pharmacology Rang and dales pharmacology