The document proposes an integrated approach for selecting the optimal combination of multiple flexible manufacturing systems (FMS). It first identifies both qualitative and quantitative attributes for evaluating FMS alternatives. Grey systems theory is used to handle uncertain qualitative data, while simulation modeling provides objective data. A goal programming model is formulated to prioritize objectives like cost, work in process, quality, etc. Finally, a genetic algorithm solves the multi-FMS combination problem by finding the combination that best meets the objectives. The proposed approach aims to facilitate complex decision making for selecting an optimal set of interrelated FMS alternatives.