![Global Health Education Consortium From Discovery to Delivery: Benchwork to Global Health Jerry Cangelosi BioAffinity Consulting Seattle Biomedical Research Institute Departments of Global Health and Epidemiology University of Washington [email_address] 256-7313 Research interests: Molecular diagnosis of infectious disease Molecular epidemiology of infectious disease](https://image.slidesharecdn.com/cangelosighecapril2009v2-090415181209-phpapp01/75/From-Discovery-to-Delivery-Benchwork-to-Global-Health-Jerry-Cangelosi-1-2048.jpg)
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From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
The document discusses the issues of tuberculosis (TB), especially among homeless populations, highlighting that TB has significant global health implications with millions of cases and deaths yearly. It emphasizes the need for timely diagnosis, case detection, and treatment decision-making to control disease transmission, particularly through the development of accessible and low-cost diagnostic technologies. Additionally, it mentions various ongoing efforts in diagnostic technology and the importance of collaborative research in this field.
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From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
- 1. Global Health EducationConsortium From Discovery to Delivery: Benchwork to Global Health Jerry Cangelosi BioAffinity Consulting Seattle Biomedical Research Institute Departments of Global Health and Epidemiology University of Washington [email_address] 256-7313 Research interests: Molecular diagnosis of infectious disease Molecular epidemiology of infectious disease
- 2. American Red CrossTuberculosis (TB) Airborne transmission 7+ million cases, 2+ million deaths per year Many people latently infected Limited vaccine (BCG) Treatment long and difficult Poorest countries have highest incidence
- 3. TB and homelessness:Tough all over National incidence (cases per 100,000 population; 2004) 1 U.S.A. 4.9 Hungary 24.5 Extrapolated incidence among the homeless (cases per 100,000; 2004) Seattle ~400 2 Budapest ~700 3 1 WHO 2 Public Health – Seattle & King County 3 National Korányi Institute for Tuberculosis and Respiratory Medicine, Budapest
- 4. TB risk factorsassociated with homelessness ___ ___ ___ ___ ___
- 5. Public Health –Seattle & King County Global Fund to Fight AIDS, Tuberculosis, and Malaria Timely diagnosis is critical to : Patient care Case detection Correct and timely treatment decisions Confirmation of treatment (test of cure) Control of disease transmission Surveillance Research and development
- 6. Diagnostic technology development1. Diagnostic technologies are modular MicroProbe Affirm VPIII test for vaginosis pathogens MBARI “ESP” for detecting harmful algae blooms
- 7. Diagnostic technology development2. Needed for global health: low cost and “point of care” Response Biomedical RAMP test for anthrax spores
- 8. Diagnostic technology development3. Biomarkers needed “ Accelerated Molecular Probe Pipeline” Entamoeba histolytica (ameobic diarrhea) Biomarkers diagnostic test Collaborators in US, Australia, Bangladesh