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Gene bank by kk sahu
- 1. Pacific Networks PacificNetworksGENBANK 01 GENBANK By KAUSHAL KUMAR SAHU Assistant Professor (Ad Hoc) Department of Biotechnology Govt. Digvijay Autonomous P. G. College Raj-Nandgaon ( C. G. )
- 2. Pacific Networks PacificNetworks SYNOPSIS INTRODUCTION OF BIOINFORMATICS HISTORY WHAT IS DATABASE NEED FOR DATABASE TYPES OF DATABASE PRIMARY DATABASE NUCLEIC ACID SEQUENCE DATABASE GEN BANK 02
- 3. Pacific Networks PacificNetworks GEN BANK 03 GENE BANK INTRODUCTION GENE BANK SUBMISSION TOOL GENE BANK SUBMISSION TYPE HOW TO RETRIEVE DATA FROM GENEBANK APPLICATION CONCLUSION REFERENCE
- 4. Pacific Networks PacificNetworksGEN BANK 04 INTRODUCTION OF BIOINFORMATICS According to old concept BI is the symbiotic relationship between computational and biological science which was originally coined for the analysis and management of biological information stored in databases. According to the new concept bioinformatics can be considered as information technology applied to the management and analysis of biological data.
- 5. Pacific Networks PacificNetworksGEN BANK O5 WHAT IS DATABASE The collection of a biological data on a computer which can be manipulated to appear in varying arrangement and subsets is regarded as database. Biological database are computer sites that organize, store and disseminate files that contain information consisting of literature references, nucleic acid sequences, protein sequence & protein structure.
- 6. Pacific Networks PacificNetworksGEN BANK 06 NEED FOR DATABASE Easy access to the information. Method for extracting specific/required data. Gene discovery. Gene function. Protein function. Drug discovery. Drug designing.
- 7. Pacific Networks PacificNetworksGEN BANK 07 TYPES OF DATABASE Primary database Composite database Secondary database
- 8. Pacific Networks PacificNetworksGEN BANK 08 PRIMARY SEQUENCE DATABASE A primary database is a database that stores biomolecular sequence (protein or nucleic acid) associated annotation information (organism, species, functions ,mutation linked to particular disease, functional/structural patterns.)
- 9. Pacific Networks PacificNetworksGEN BANK 09 NUCLEIC ACID DATABASE DNA and protein are complicated 3D molecules, composed of thousands or even millions of atoms bonded together. DNA and proteins are both polymers, chains of repeating chemical units with a common backbone holding together. In DNA four nucleic acid monomers (A,T,C and G) are commonly used to build the polymer chain, the four nucleic acids can occur in any order, and the order they occur determines what the DNA does.
- 10. Pacific Networks PacificNetworksGEN BANK 10 THERE ARE THREE PRINCIPLE TYPES OF DATABASE GENBANK EMBL (Europe) DNA Data Bank Japan (DDBJ)
- 11. Pacific Networks PacificNetworksGENBANK 11 Genebank EMBL (USA) (Europe) DDBJ Three Principle DNA Sequence Database
- 12. Pacific Networks PacificNetworksGEN BANK 12 GenBank is the DNA database from the National Centre for Biotechnology Information (NCBI). NCBI is a division of National Library of Medicine, located at National Institute of health (NIH) in Bethesda in Maryland . It incorporates sequences from publicly available sources ,primary from direct author submission and large scale sequencing projects. GenBank
- 13. Pacific Networks PacificNetworksGEN BANK 13 NCBI maintain sequence maintain from every organism, every source, every type of DNA from mRNA to cDNA to clone to expressed sequence tags (ETSs) to high throughput genome sequencing data and information about sequence polymorphisms. There are approximately 126,551,501,141 bases in 135,440,924 sequence records in the traditional GenBank divisions and 191,401,393,188 bases in 62,715,288 sequence records in the division of April 2011. Reference-www.ncbi.nlm.nih.gov/genbank/
- 14. Pacific Networks PacificNetworks GenBank Search : Main Sequence Types GENBANK 14
- 15. Pacific Networks PacificNetworksGEN BANK 15 PRI ROD MAM VRT INV PLA BCT RNA VRL Primate Rodent Mammalian Vertebrate Invertebrate Plant, Fungal Bacterial Structural RNA Viral PHG SYN EST PAT STS GSS Bacteriophage Synthetic Expressed Sequence Tags Patent Sequence tagged sites Genome Survey Sequence The increasing size of the database and the diversity of data sources available have made it convenient to split Genebank into smaller discrete division.
- 16. Pacific Networks PacificNetworksGEN BANK 16 GENBANK SUBMISSION TYPE GenBank accepts mRNA or genomic sequence data directly determined by the submitter. The submission must include information about the source organism and annotation provided by the submitter. More details about adding annotation and sample files can be found in the GenBank Submissions Handbook
- 17. Pacific Networks PacificNetworks The following data is not accepted by GenBank Primer sequences Protein sequences with no underlying nucleotide submission Sequence containing a mix of genomic and mRNA sequence Sequences with length less than 200 nucleotides GEN BANK 17
- 18. Pacific Networks PacificNetworksGEN BANK 18 HOW TO SUBMIT DATA TO GENBANK The most important source of new data for GenBank is direct submissions from scientists. GenBank depends on its contributors to help keep the database as comprehensive, current, and accurate as possible. NCBI provides timely and accurate processing and biological review of new entries and updates to existing entries, and is ready to assist authors who have new data to submit.
- 19. Pacific Networks PacificNetworksGEN BANK 19 Receiving an Accession Number for your Manuscript Most journals require DNA and amino acid sequences that are cited in articles be submitted to a public sequence repository (DDBJ/EMBL/Genbank) as part of the publication process. Data exchange between DDBJ, EMBL and GenBank occurs daily so it is only necessary to submit the sequence to one database, whichever one is most convenient, without regard for where the sequence may be published.
- 20. Pacific Networks PacificNetworksGEN BANK 20 Updating or Revising a GenBank Sequence Revisions or updates to GenBank entries can be made by the submitters at any time. Information about the correct format for different types of updates can be found on the Update guidelines page.
- 21. Pacific Networks PacificNetworksGEN BANK 21 Confidentiality Some authors are concerned that the appearance of their data in GenBank prior to publication will compromise their work. GenBank will, upon request, withhold release of new submissions for a specified period of time. However, if a paper citing the sequence or accession number is published prior to the specified date, your sequence will be released upon publication.
- 22. Pacific Networks PacificNetworksGEN BANK 22 Privacy If you are submitting human sequences to GenBank, do not include any data that could reveal the personal identity of the source. It is our assumption that you have received any necessary informed consent authorizations that your organizations require prior to submitting your sequences.
- 23. Pacific Networks PacificNetworks HOW TO RETRIEVE DATA FROM GENBANK 5/10/2020 12:02 PM 23
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- 29. Pacific Networks PacificNetworksGENBANK 29 APPLICATIONS OF GENBANK SEQUENCE ALIGNMENTS PRIMER DESIGNING GENE EXPRESSION AND DNA MICROARRAY IN CROP IMPROVEMENT IN EVOLUTION .
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- 31. Pacific Networks PacificNetworks GEN BANK 31 References 1.Bioinformatics :C.S.V.Murthy 2.BIOINFORMATICS : David W.Mount 3.By Internets www.ncbi.nlm.nih.gov/genbank/ www.ncbi.nlm.nih.gov › NCBI› DNA & RNA