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Similar to Gout present by sarim .....
Gout present by sarim .....
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- 6. GOUT is aresult of prolonged, untreated and high uric acid level in the bloodstream. The condition is also referred to as the 'Disease of Kings' or the 'Rich Man's Disease’ Mostly observed in the men but also affects women with menopause and other body parts or joints as well.
- 7. It is accompaniedby fever, intense joint pain and inflammation of the tissues , in and around the affected joint. Gout attacks the big toe, heel, ankle, wrist, knee , fingers, elbow and/or the spine. There have been cases where the condition has arisen out of immobility caused to joints due to a previous injury. Similarly , hyperuricemia patients also develop tophi or uric acid crystal deposits in tissues such as observed in the pinnae of the ear.
- 8. Different joints that maybe involve in gout. But at a time only one joint is involve in gout.
- 9. The most commonjoint involve is METATARSOPHALANGIAL JOINT OF BIG TOE.
- 11. Primary gout isdue to the high level of uric acid in blood that is hyperuricemia which may be due to kidney problem and /or intake of protien-rich food(purine rich food) , alcohol and/or other herediatry factors causes obesity , diabetes, hypertension and heart diseases.
- 14. That arise fromother medical conditions like metabolic syndrome and blood cancer or leukemia. Diuretics can also cause gout.
- 15. 1..In human, sodium urateis the end product of purine metabolism. 2.Deposition of urate crystals initiates an inflammatory process. 3.Granulocytes phagocytize urate crystals , lysosomal enzyme evoke an inflammatory response. 4.Production of lactate in synovial fluid. 5.Local decrease in pH fosters further deposition of urate crystals.
- 17. Gout is suspectedwhen a patient reports a history of attacks of painful arthritis, particularly at the base of the toes. Ankles and knees are the next most commonly involved joints in gout. Gout usually attacks one joint at a time .
- 18. . The most reliabletest for gout is finding uric acid crystals in a sample of the joint by joint aspiration. Microscopic analysis of uric acid crystals …. X-RAY image analysis… BLOOD URIC ACID LEVEL .. Normally the blood uric acid level is less than 6.8mg/dL.
- 19. And the othertest which also help to diagnose gout is BLOOD URIC ACID LEVEL .. Normally the blood uric acid level is less than 6.8mg/dL . .
- 23. E.G .. Allopurinol E.G.. Febuxostat E.G .. Probenecid , Sulfinpyrazone
- 24. Inhibit leukocytes migrationto joints . Like Indomethacin, Mefenamic Acid