Heart disease is the number one cause of death worldwide. It is caused by a buildup of fatty deposits called plaque in the coronary arteries that supply blood to the heart. This buildup is known as atherosclerosis and can lead to coronary artery disease. Risk factors include age, family history, high cholesterol, smoking, high blood pressure, diabetes, obesity, and physical inactivity. To prevent heart disease, one should eat a healthy diet low in fat and cholesterol, exercise regularly, maintain a healthy weight, not smoke, control blood pressure and cholesterol levels, and see a doctor to monitor risk factors. Making lifestyle changes can significantly reduce risk and help live a longer, healthier life.