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HEME SYNTHESIS
This document outlines the steps in the synthesis of heme from succinyl CoA and glycine. Heme synthesis involves 10 enzymatic steps that convert succinyl CoA and glycine into protoporphyrin IX, which is then combined with iron by ferrochelatase to produce heme. Key intermediates include δ-aminolevulinate, porphobilinogen, uroporphyrinogen III, coproporphyrinogen III, and protoporphyrinogen III.
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HEME SYNTHESIS
- 1. Succinyl CoA Glycine δ-Aminolevulinate 2 δ- Aminolevulinate Porphobilinogen 4-Porphobilinogen Uroporphyrinogen III Coproporphyrinogen III Protoporphyrinogen III Protoporphyrin IX Heme δ- Aminolevulinate Synthase δ- Aminolevulinate dehydratase Uroporphyrinogen I Synthase & uroporphyrinogen III cosynthase Uroporphyrinogen decarboxylase Coprophyrinogen oxidase Protophyrinogen oxidase Ferrochelatase Fe2+ 4H+ 4CO2 4CO2 4NH3 4H2O CoASH Synthesis of heme