This three-part document discusses hemodialysis prescription and targets. It begins with an introduction and overview of hemodialysis history and statistics on end-stage renal disease from the USRDS 2020 report. Part I covers breaking the news to patients about needing dialysis and variables in deciding on dialysis. Parts II and III will discuss choosing filters and dialysate composition, hemodynamics, ultrafiltration, and research aspects of optimizing hemodialysis prescription. The goal is targeting a dialysis treatment that is friendly to patients.