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HISTOPLASMOSIS.pptx
This document discusses histoplasmosis, an infection caused by the fungus Histoplasma capsulatum. The fungus lives in soil containing bird or bat droppings. There are two main types - pulmonary histoplasmosis, which occurs when the fungus is inhaled, and disseminated histoplasmosis, which spreads from the lungs. Symptoms can include fever, cough, fatigue and chest pain. Diagnosis involves examining samples under a microscope for the yeast cells or culturing samples. Treatment uses antifungal medications such as itraconazole or amphotericin B, depending on severity.
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Histoplasmosis is a fungal infection caused by Histoplasma Capsulatum, also known as cave disease and others.
Histoplasma is a dimorphic fungus with both mycelial and yeast forms, having unique reproductive structures.
The infection primarily presents in two forms: pulmonary and disseminated histoplasmosis.
This type begins with inhalation of spores, leading to various conditions like asymptomatic and chronic forms.
Symptoms include fever, cough, and fatigue, appearing 3-17 days post-exposure, especially in immunocompromised.
Prevention involves avoiding exposure to the fungus and spraying contaminated areas to prevent spore release.
Diagnosis includes specimen testing, direct examination of stained samples, cultures, serological tests and skin tests.
Diagnosis includes specimen testing, direct examination of stained samples, cultures, serological tests and skin tests.
Diagnosis includes specimen testing, direct examination of stained samples, cultures, serological tests and skin tests.
Treatment involves antifungal medications like Itraconazole, with durations depending on severity, up to 1 year.
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HISTOPLASMOSIS.pptx
- 1. HISTOPLASMOSIS Presented By Vigneshwari.D 1ST M.ScMicrobiology Sacred Heart College(Autonomos) Tirupattur.
- 2. HISTOPLASMOSIS • Histoplasmosis isan infection caused by a fungus called Histoplasma Capsulatum. • The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings.
- 3. It is alsoknown as.... • Cave disease, • Darling's disease, • Ohio valley disease, • Reticuloendotheliosis, • Spelunker's lung and Caver's disease..
- 4. General Characteristics • Dimorphicfungus - Sexual multi-cellular saprophytic mycelia - Asexual single-celled parasitic yeast • Mycelial form most commonly found in the environment. • Heteroth allic species. • Tightly Coiled septate hyphae • Smooth,hyline,spherical Ascospores • Globose cleistothecia • Pear – shaped asci
- 5. • Condia germinatevia non/polar budding. • Yeast form is the infectious agent in humans. • Yeast cells have white,thin-walled,oval bodies. • Form sexual macro – and microconidia - Also borne by hyphae in the mycelial form.
- 6. Histoplasmosis - Types •Two major forms of histoplasmosis 1)Pulmonary histoplasmosis 2)Disseminated histoplasmosis
- 7. Pulmonary histoplasmosis • Pulmonaryhistoplasmosis occurs when microconidia or mycelial fragments are inhaled. • Form lesions in the hilar or mediastainal nodes.
- 8. Pulmonary histoplasmosis types 1.Asymptomaticpulmonary histoplasmosis 2.Acute pulmonary histoplasmosis 3.Mediastinal granuloma 4.Fibrosing mediastinitis 5.Chronic cavity pulmonary histoplasmosis
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- 11. Clinical Manifestations • Mostpeople who are exposed to the fungus Histoplasma never have symptoms. • Fever • Cough • Fatigue (extreme tiredness) • Chills • Headache • Chest pain • Body aches
- 12. • Symptoms ofhistoplasmosis may appear between 3 and 17 days after a person breathes in the fungal spores. • In some people, usually those who have weakened immune systems, histoplasmosis can develop into a long-term lung infection, or it can spread from the lungs to other parts of the body, such as the central nervous system (the brain and spinal cord).
- 13. PREVENTION • Avoid exposure.Avoid projects and activities that might expose you to the fungus, such as cave exploring and raising birds, such as pigeons or chickens. • Spray contaminated surfaces. Before you dig soil or work in an area that could harbor the fungus that causes histoplasmosis, soak it with water. This can help prevent spores from being released into the air. Spraying chicken coops and barns before cleaning them also can reduce your risk.
- 14. Laboratory diagnosis 1.Specimens • Sputum •Bone- marrow aspirate • Peripheral blood • Scrapings from dermal or mucosal ulcers • Biopsy of lymph nodes and other organs
- 15. 2.Direct examination • Smearsof sputum or pus are stained with giemsa or wright stains. • In tissues,the yeast phase occurs within phagocytic cells • The yeast appers as an oval,budding cell measuring 2-4 µm while in african histoplasmosis,much larger yeast –like cells(7- 15µm) are seen.
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- 17. 3.Culture • SDA orbrain heart infusion (BHI) agar with cyloheximide and chloramphenicol are inoculated. • The yeast phase is formed in culture at 37°C . • White cottony mycelial growth containing large (8-20 µm) thick walled ,spherical spores with tubercles or finger like projections appears at 25°C.
- 19. 3.Serological tests • Latexaggultination precipitation and complement fixation tests become positive two weeks after infection. • Increase in titre of antibody indicates a progressive disease.
- 20. 4.Histoplasmin skin test •Delayed hypersensitivity test. • The test is similar to tuberculin test but antigen used is histoplasmin. • Histoplasmin is a culture filtrate antigen of mycelial phase of H.capsulatum. • A positive ‘histoplasmin skin test’ indicates past or present infection,but does not differentiate active and past infections.
- 21. • Diagnosing histoplasmosiscan be complicated, depending on what parts of your body are affected. • While testing might not be necessary for mild cases of histoplasmosis, it can be crucial in treating life-threatening cases.
- 22. Treatment • Itraconazole isone type of antifungal medication that's commonly used to treat histoplasmosis. • Depending on the severity of the infection and the person's immune status, the course of treatment can range from 3 months to 1 year. • Many people will need antifungal treatment for histoplasmosis.
- 23. • Severe infectionsor disseminated cases of histoplasmosis require treatment with antifungal medications. • Itraconazole • fluconazole • amphotericin B • drug of choice for severe disease are antifungal drugs that treat histoplasmosis.