Hospital-acquired infections are common in intensive care unit patients due to factors like severity of illness, mechanical ventilation, malnutrition, and prolonged ICU stay. The most frequent mode of transmission is contact, either direct or indirect. Common infections acquired in the ICU include ventilator-associated pneumonia, urinary tract infections, and central line-associated bloodstream infections. Preventing these infections requires following protocols for sterile insertion and care of devices, hand hygiene, and using protective equipment during patient care.