Titanium Mobile allows developers to build native mobile apps using JavaScript. It works by compiling JavaScript code into the native platform's code (Java for Android, Objective-C for iOS). This allows apps built with Titanium to have access to native device APIs and feel and function like a true native app while using a common JavaScript codebase. Titanium Studio is the IDE used for Titanium development and provides features like code completion, debugging, and building for release. Projects have a standard structure with resources, modules, and code files organized into platform-specific folders. Internationalization is supported by creating language-specific string files.