Cross-Site Scripting (XSS) is a security vulnerability that enables attackers to inject client-side scripts (usually JavaScript) into web pages, potentially compromising users' private data and enabling unauthorized actions. Types of XSS attacks include non-persistent, persistent, and DOM-based, each affecting data differently, with persistent XSS being the most dangerous due to its ability to affect multiple users. Preventative measures involve stringent input validation and output sanitization to block malicious code from being processed by servers and browsers.