Stress
Brian J. Piper, Ph.D.
Stress and Health
   Stress and Illness
   Stress and the Heart
   Stress and Susceptibility to Disease
Stress and Health
Psychological states cause physical illness. Stress
  is any circumstance (real or perceived) that
        threatens a person’s well-being.




When we feel severe stress, our ability to cope with it is
                      impaired.
Stress and Health
   Stress can be adaptive. In a fearful or stress-
causing situation, we can run away and save our
                         lives.
   Stress can be maladaptive. If it is prolonged
(chronic stress), it increases our risk of illness and
                  health problems.




                        Stress
Stress and Stressors

  Stress is a slippery concept. At times it is the
stimulus (missing an appointment) and at other
 times it is a response (sweating while taking a
                        test).
Stress and Stressors
Stress is not merely a stimulus or a response. It is
 a process by which we appraise and cope with
      environmental threats and challenges.




                                                              Bob Daemmrich/ The Image Works
When short-lived or taken as a challenge, stressors may
have positive effects. However, if stress is threatening or
              prolonged, it can be harmful.
The Stress Response System
Walter Cannon proposed
  that the stress response
(fast) was a fight-or-flight
 response marked by the
outpouring of epinephrine
 and norepinephrine from
the inner adrenal glands
   (medulla), increasing
   heart and respiration
  rates, and dulling pain.
                               Medulla: Epinephrine
                               Cortex: Cortisol
Evolutionary Psychology
• Robert Sapolsky
• 0:15 – 3:58:
 http://www.youtube.com/watch?v=sPS7GnromGo
General Adaptation Syndrome
According to Selye, a stress response to any kind of
stimulation is similar. The stressed individual goes
               through three phases.
General Adaptation Syndrome
                               Alarm
  “Fight or Flight” reaction: body mobilizes resources to combat threat; activates the
  sympathetic nervous system.



                           Resistance
   Enhanced ability to fight stressor via moderate physiological arousal; ability to
   withstand additional stressors (e.g., infection) is reduced.




                           Exhaustion
Depletion of resources brings on diseases and disorders (e.g., chronically high heart
rate and blood pressure increase chances of heart attack and stroke).
3 min: http://www.youtube.com/watch?v=YJCeDtNh_Aw
Chronic Stress &
                 Neurogenesis
•   Rats were exposed to 125 dB 12kHz noises for 2 hours/day for 10
    weeks
•   Hippocampampal tissue was processed for doublecortin for new
    neurons (subgranular zone or SGZ).




                                                                        *



                                  Kraus et al. (2010). Neuroscience, 167, 1216-1226.
Stressful Life Events
 Catastrophic Events: Catastrophic events like
  earthquakes, combat stress, and floods lead
individuals to become depressed, sleepless, and
                   anxious.
Significant Life Changes
The death of a loved one, a divorce, a loss of job,
or a promotion may leave individuals vulnerable
                   to disease.
Stress & Lifespan?
• Top Causes of Death (2009):
  –   Heart Disease
  –   Cancer
  –   Chronic respiratory diseases
  –   Stroke
  –   Accidents
  –   Alzheimer’s
  –   Diabetes
  –   Influenza & pneumonia
  –   Kidney disease
  –   Suicide      http://www.cdc.gov/nchs/data/nvsr/nvsr59/nvsr59_04.pdf
Stress& Lifespan?
Expected Lifespan (2009):
   – Caucasian Males: 76.2
   – Caucasian Females: 80.9
   – African American Males: 70.9
   – African American Females: 77.4




 Center for Disease Control, 2009
Health-Related Consequences
                              Stress can have a variety of health-related
                                            consequences.
Kathleen Finlay/ Masterfile
Stress and the Heart
   Stress that leads to elevated blood pressure may
  result in coronary heart disease, a clogging of the
        vessels that nourish the heart muscle.



   Plaque in
                                               Artery
coronary artery
                                              clogged
Personality Types
Type A is a term used by Meyer Friedman for
competitive, hard-driving, impatient, verbally                  1910-2001
aggressive, and anger-prone people.
Type B refers to easygoing, relaxed people.

          Type A personalities are more likely to die from
                     coronary heart disease.

                               Total (3154)    CHD Death (50)
            A                  1589 (50.4%)    34 (68%)
            B                  1565 (49.6%)    16 (32%)



 Rosenman et al. (1975). JAMA, 233, 872-877.
Pessimism and Heart Disease
     Pessimistic adult men (sample = 2000 Veterans)
    are twice as likely to develop heart disease over a
                      10-year period.




Kubzansky et al. (2001). Psychosomatic Medicine, 63, 910-916.
Stress & Susceptibility to Disease
A psychophysiological illness is any stress-related
 physical illness such as hypertension and some
                    headaches.

 Psychoneuroimmunology (PNI) is a developing
field in which the health effects of psychological,
 neural, and endocrine processes on the immune
               system are studied.
Psychoneuroimmunology

B lymphocytes fight bacterial infections
T lymphocytes attack viruses and cancer cells
microphages ingest foreign substances
  During stress, energy is mobilized away from
    the immune system making it vulnerable.
Stress and Colds
People with the highest life stress scores were also
    the most vulnerable when exposed to an
             experimental cold virus.
Stress and AIDS
 Stress and negative emotions may accelerate the
progression from human immunodeficiency virus
 (HIV) to acquired immune deficiency syndrome
                     (AIDS).
HIV Worldwide




            UN AIDS/WHO, 2004 Data
Stress and Cancer

  Stress does not create cancer cells. Researchers
     disagree on whether stress influences the
  progression of cancer. However, they do agree
that avoiding stress and having a hopeful attitude
         cannot reverse advanced cancer.
Behavioral Medicine

Psychologists and physicians have developed an
 interdisciplinary field of behavioral medicine
   that integrates behavioral knowledge with
               medical knowledge.

“Mind” and body interact; everything psychological
        is simultaneously physiological.
Summary
• GAS
• Stress & Health
Course Summary
• Biopsychosocial
• Comparative
• Scientific process (Question authorities!)

Introductory Psychology: Stress

  • 1.
  • 2.
    Stress and Health  Stress and Illness  Stress and the Heart  Stress and Susceptibility to Disease
  • 3.
    Stress and Health Psychologicalstates cause physical illness. Stress is any circumstance (real or perceived) that threatens a person’s well-being. When we feel severe stress, our ability to cope with it is impaired.
  • 4.
    Stress and Health Stress can be adaptive. In a fearful or stress- causing situation, we can run away and save our lives. Stress can be maladaptive. If it is prolonged (chronic stress), it increases our risk of illness and health problems. Stress
  • 5.
    Stress and Stressors Stress is a slippery concept. At times it is the stimulus (missing an appointment) and at other times it is a response (sweating while taking a test).
  • 6.
    Stress and Stressors Stressis not merely a stimulus or a response. It is a process by which we appraise and cope with environmental threats and challenges. Bob Daemmrich/ The Image Works When short-lived or taken as a challenge, stressors may have positive effects. However, if stress is threatening or prolonged, it can be harmful.
  • 7.
    The Stress ResponseSystem Walter Cannon proposed that the stress response (fast) was a fight-or-flight response marked by the outpouring of epinephrine and norepinephrine from the inner adrenal glands (medulla), increasing heart and respiration rates, and dulling pain. Medulla: Epinephrine Cortex: Cortisol
  • 8.
    Evolutionary Psychology • RobertSapolsky • 0:15 – 3:58: http://www.youtube.com/watch?v=sPS7GnromGo
  • 9.
    General Adaptation Syndrome Accordingto Selye, a stress response to any kind of stimulation is similar. The stressed individual goes through three phases.
  • 10.
    General Adaptation Syndrome Alarm “Fight or Flight” reaction: body mobilizes resources to combat threat; activates the sympathetic nervous system. Resistance Enhanced ability to fight stressor via moderate physiological arousal; ability to withstand additional stressors (e.g., infection) is reduced. Exhaustion Depletion of resources brings on diseases and disorders (e.g., chronically high heart rate and blood pressure increase chances of heart attack and stroke). 3 min: http://www.youtube.com/watch?v=YJCeDtNh_Aw
  • 11.
    Chronic Stress & Neurogenesis • Rats were exposed to 125 dB 12kHz noises for 2 hours/day for 10 weeks • Hippocampampal tissue was processed for doublecortin for new neurons (subgranular zone or SGZ). * Kraus et al. (2010). Neuroscience, 167, 1216-1226.
  • 12.
    Stressful Life Events Catastrophic Events: Catastrophic events like earthquakes, combat stress, and floods lead individuals to become depressed, sleepless, and anxious.
  • 13.
    Significant Life Changes Thedeath of a loved one, a divorce, a loss of job, or a promotion may leave individuals vulnerable to disease.
  • 14.
    Stress & Lifespan? •Top Causes of Death (2009): – Heart Disease – Cancer – Chronic respiratory diseases – Stroke – Accidents – Alzheimer’s – Diabetes – Influenza & pneumonia – Kidney disease – Suicide http://www.cdc.gov/nchs/data/nvsr/nvsr59/nvsr59_04.pdf
  • 15.
    Stress& Lifespan? Expected Lifespan(2009): – Caucasian Males: 76.2 – Caucasian Females: 80.9 – African American Males: 70.9 – African American Females: 77.4 Center for Disease Control, 2009
  • 16.
    Health-Related Consequences Stress can have a variety of health-related consequences. Kathleen Finlay/ Masterfile
  • 17.
    Stress and theHeart Stress that leads to elevated blood pressure may result in coronary heart disease, a clogging of the vessels that nourish the heart muscle. Plaque in Artery coronary artery clogged
  • 18.
    Personality Types Type Ais a term used by Meyer Friedman for competitive, hard-driving, impatient, verbally 1910-2001 aggressive, and anger-prone people. Type B refers to easygoing, relaxed people. Type A personalities are more likely to die from coronary heart disease. Total (3154) CHD Death (50) A 1589 (50.4%) 34 (68%) B 1565 (49.6%) 16 (32%) Rosenman et al. (1975). JAMA, 233, 872-877.
  • 19.
    Pessimism and HeartDisease Pessimistic adult men (sample = 2000 Veterans) are twice as likely to develop heart disease over a 10-year period. Kubzansky et al. (2001). Psychosomatic Medicine, 63, 910-916.
  • 20.
    Stress & Susceptibilityto Disease A psychophysiological illness is any stress-related physical illness such as hypertension and some headaches. Psychoneuroimmunology (PNI) is a developing field in which the health effects of psychological, neural, and endocrine processes on the immune system are studied.
  • 21.
    Psychoneuroimmunology B lymphocytes fightbacterial infections T lymphocytes attack viruses and cancer cells microphages ingest foreign substances During stress, energy is mobilized away from the immune system making it vulnerable.
  • 22.
    Stress and Colds Peoplewith the highest life stress scores were also the most vulnerable when exposed to an experimental cold virus.
  • 23.
    Stress and AIDS Stress and negative emotions may accelerate the progression from human immunodeficiency virus (HIV) to acquired immune deficiency syndrome (AIDS).
  • 24.
    HIV Worldwide UN AIDS/WHO, 2004 Data
  • 25.
    Stress and Cancer Stress does not create cancer cells. Researchers disagree on whether stress influences the progression of cancer. However, they do agree that avoiding stress and having a hopeful attitude cannot reverse advanced cancer.
  • 26.
    Behavioral Medicine Psychologists andphysicians have developed an interdisciplinary field of behavioral medicine that integrates behavioral knowledge with medical knowledge. “Mind” and body interact; everything psychological is simultaneously physiological.
  • 27.
  • 28.
    Course Summary • Biopsychosocial •Comparative • Scientific process (Question authorities!)

Editor's Notes

  • #4 Preview Question 1: What is stress?
  • #13 Preview Question 2: What events provoke stress responses?
  • #18 Preview Question 3: Why are some of us more prone than others to coronary heart disease?
  • #21 Preview Question 4: How does stress make us more vulnerable to disease?