JavaScript is a client-side scripting language that is commonly used to add interactivity to web pages. The Document Object Model (DOM) represents the structure of an HTML/XML document and allows JavaScript to dynamically access and update the content, structure, and styling of a document. Asynchronous JavaScript and XML (AJAX) is a set of web development techniques that allow web pages to be updated asynchronously by exchanging data with a web server behind the scenes, without reloading the entire page. jQuery is a popular JavaScript library that simplifies tasks like HTML document traversal and manipulation, events, animations, and Ajax interactions for rapid web development.