Unit testing JavaScript code involves writing tests for individual units or components, such as classes or functions, to validate their behavior. There are several frameworks for writing unit tests in JavaScript, including QUnit, Jasmine, Mocha, and custom frameworks. Best practices for unit testing include writing one test per class method to validate inputs and outputs, moving larger tests to integration tests, and making tests easy to read. Common testing concepts include describing and grouping tests, setting up contexts and fixtures, using spies and stubs, and making assertions.