Lean Six Sigma is a combination of Lean methodology and Six Sigma that aims to improve quality by identifying and removing waste and reducing variation. It was developed in the 1980s at Motorola and has since been applied in healthcare to improve various processes and outcomes. Key aspects of Lean Six Sigma include defining problems, measuring processes, analyzing sources of variation, improving processes by eliminating waste, and controlling improvements. The goals are to increase customer satisfaction, improve speed and quality of service, and lower costs through reducing defects and waste.