Lean Six Sigma is a methodology that combines Lean principles, focused on reducing waste, with Six Sigma's data-driven approach to minimize defects and process variation. It emphasizes continuous improvement through its DMAIC framework (Define, Measure, Analyze, Improve, Control) and is applicable across various industries, showcasing principles such as focusing on value and streamlining processes. Key tools and techniques include SIPOC, 5 Why analysis, and FMEA for enhancing process performance and achieving high levels of quality.