The document discusses maximum likelihood estimation. It begins by explaining that maximum likelihood chooses parameter values that make the observed data most probable given a statistical model. This provides a justification for estimation techniques like least squares regression. The document provides an example of estimating a population proportion from a sample. It then generalizes maximum likelihood to cover a wide range of models and estimation problems. It discusses properties like consistency, efficiency, and how to conduct hypothesis tests based on maximum likelihood. Numerical optimization techniques are often required to find maximum likelihood estimates for complex models.