LEFT VENTRICULAR ANGIOGRAM
SHYAM SASIDHARAN
TARGETS
 INTRODUCTION
 INDICATIONS
 EQUIPMENT
 PROCEDURE
 COMPLICATIONS
 NORMAL LV ANGIOGRAM
 CALCULATION OF LV FUNCTION
 MITRAL REGURGITATION
 VSD
 SPOTTERS
INTRODUCTION
 In 1929 Werner Forssman, inserted a urologic
catheter into his right atrium from a left antecubital
vein cut down he had performed on himself using a
mirror.
 Retrograde left heart catheterization was first done
by Zimmerman,Limon Lason & Bouchard in 1950’s
(Nobel prize in 1956).
 Used to be the only method available for assessing
LV segmental dysfunction.
INDICATIONS
 Define the anatomy and function of left ventricle.
 Global and segmental LV function-qualitative and
quantitative
 Mitral valvular regurgitation
 Congenital heart disease –VSD
 Cardiomyopathy
 LV non compaction.
EQUIPMENT
 1.INJECTION CATHETERS
-large amount of contrast in short
period of time.
-6F/7F/8F catheter with multiple side
holes.
-angled(145-155) pigtail catheters
-straight tip ventriculographic
catheters- sones catheter,
NIH,eppendorf catheters,Lehmann
catheter.
-Balloon tip ventriculographic
catheters- Berman
Equipment..
2.Power injectors – flow
injectors (Medrad)
- volume and rate of
delivery can be selected
- maximal pressure limit
of 1000psi
- can be synchronised
with R wave
- hand injection should
be avoided.
EQUIPMENT…
 3.Biplane ventriculography
better than single plane
ventriculography.
-more information at no
additional risk.
-single injection of contrast.
 Disadvantages-
higher cost
additional time
Reduced quality of
cineangiographic images
PROCEDURE
 Approach to LV–
Retro aortic ,injection directly into the
ventricles
Anterograde/trans septal approach
Apical left ventricular puncture
 Optimal catheter position –midcavitary
adequate delivery to body and apex
will not interfere with MV function
less endocardial staining and ventricular
ectopy
PROCEDURE..
 Cine left ventriculography with
contrast vol – 30-36ml
rate – 10-12ml/sec(pig tail)
- 7-10 ml/sec(sones)
 Older imaging systems required image acquisition at
deep inspiration.
 Newer imaging systems permits imaging during
normal quite breathing.
FILMING PROJECTION AND TECHNIQUE
 Cine left ventriculography
– 15-30 frames/sec
 Typically 30 deg RAO and
60 deg LAO views are
obtained
 30 deg RAO
eliminates overlap of LV
and the vertebral column
anterior apical inferior
segmental wall motion
mitral valve profile ideal
for assessment of MR
FILMING PROJECTION..
 60 deg LAO
- assess ventricular
septal integrity and
motion
- lateral and posterior
segmental function
- aortic valvular anatomy
-15-30 deg cranial
angulation for profiling
entire IVS
VIEWS FOR SPECIFIC CONDITIONS
CONDITION VIEW
LV FUNCTION 30 RAO/60 LAO
MEMBRANOUS VSD 70 LAO 30 CRANIAL / RAO
MUSCULAR VSD 4-C PROJECTION(45LAO-45CRANIAL)
70 LAO 30 CRANIAL / RAO
AVSD 4-C PROJECTION(45LAO-45CRANIAL)
45RAO-45CRANIAL
LVOTO 70 LAO 30 CRANIAL / RAO
DORV 70 LAO 30 CRANIAL / RAO
D-TGA 70 LAO 30 CRANIAL / RAO
L-TGA RAO CRANIAL/LAO CRANIAL
NORMAL LV ANGIOGRAM -SCHEMATIC
NORMAL LV ANGIOGRAM
RAO DIASTOLIC FRAME RAO SYSTOLIC FRAME
NORMAL LEFT VENTRICULOGRAM
LV FUNCTION ASSESSMENT
 Cineventriculography
was the first method
introduced in the routine
practice to determine
the LVEF.
 The area-length
technique is the most
widely used method to
quantify the left
ventricular diastolic and
systolic volumes.
LV FUNCTION ASSESSMENT
 MEASURE
Ventricular dimension
Area
Wall thickness
 DERIVE
Chamber volume
Ejection Fraction
LV mass
LV wall stress
STEPS IN LV VOLUME CALCULATION
 1.Tracing LV outline or
silhoutte
 2.Marking aortic valve
border
 3.Calculation of LV
volume by computer
based algorithms
 4.Magnification
correction
 5.Applying Regression
Equation
 Angiographic stroke
volume,SV = EDV –
ESV
 Ejection fraction,EF =
(EDV – ESV) / EDV
 LV wall thickness,h is
measured at end
diastole at LV free wall
2/3 distance from aortic
valve to apex in RAO
 LV Mass = Vc+w - VC
CALCULATION OF LV MASSCALCULATION OF LV EF
LV FUNCTION ASSESSMENT..
GLOBAL LV DYSFUNCTION
REGIONAL LV DYSFUNCTION
 Regional wall motion can be graded qualitatively as
normal, hypokinetic, akinetic, dyskinetic,or
hyperkinetic.
 The analyses of the RAO and LAO projections as
the following segments:
REGIONAL LV DYSFUNCTION…
CORONARY ARTERY SEGMENTS
LAD
Anterolateral
Apical
Septal
Diagonal branches Anterolateral
Ramus intermedius Anterolateral
Superolateral
Left circumflex (dominant RCA)
Posterolateral
Superolateral
Dominant right coronary artery
Posterobasal
Diaphragmatic
Inferolateral
MITRAL REGURGITATION
 Diagnosis and assessment of severity of MR
DEGREE VENTRICULOGRAPHIC CRITERIA
1+ Faint opacification of the left atrium with clearing of
contrast during each beat
2+ Opacification of the atrium that does not clear but is
not as dense as the left ventricle
3+ Opacification of the atrium with the same density as
the ventricle
4+ Immediate, dense opacification of the atrium with
filling of the pulmonary veins
MR - REGURGITANT FRACTION
 Angiographic quantification of MR
 Total Stroke Volume (TSV = EDV – ESV) calculated
from LVgram.
 Forward Stroke Volume(FSV) calculated by Fick
method or indicator dilution technique.
 Regurgitant Stroke Volume (RSV) = TSV – FSV
 Regurgitant Fraction (RF) = RSV/TSV
ANGIO GRADE DOPPLER RF(%) ANGIO RF(%)
1 28 +/- 9 <20
2 38 +/- 9 21 - 40
3 44 +/- 10 41 - 60
4 59 +/- 12 >60
MITRAL REGURGITATION
HYPERTROPHIC CARDIOMYOPATHIES
 In HCM, cavity obliteration
is commonly seen together
with small ventricular end-
systolic volumes .
 Systolic anterior motion of
the mitral valve may result
in severe degrees of mitral
regurgitation.
 The ventriculogram in the
apical variant typically
appears with a “spade”-
shaped contour.
TAKO TSUBO CARDIOMYOPATHY
 Diffuse akinesis of LV
apex with preserved
basal contractilty.
 Characteristically
resemble the shape of a
japanese octopus
trap(tako-tsubo)
VENTRICULAR SEPTAL DEFECT
 A standard view in the
evaluation of patients
with ASDs or muscular
VSDs is the
hepatoclavicular view
at 30◦ to 45◦ LAO and
30◦ to 45◦ cranial
COMPLICATIONS…
 Ventricular extrasystole –
mechanical stimulation
 Ventricular tachycardia –
mostly NSVT
 Intramyocardial
injection/endocardial
staining
 Myocardial perforation
 Left anterior fascicular
block
 Transient complete heart
block
 Embolism- air/thrombus
 Complications of contrast
media
SPOTTER 1
SPOTTER 2
SPOTTER 3
SPOTTER 4
SPOTTER 5
SPOTTER 6
SPOTTER 7
SPOTTER 8
SPOTTER 9
SPOTTER 10
“STACK OF COINS” APPEARANCE
SPOTTER 11
SPOTTER 12
SPOTTER 13
SPOTTER14
SPOTTER 15
SPOTTER 16
SPOTTER 17
SPOTTER18
SPOTTER 19
THANK YOU..

Left ventricular angiogram (1)

  • 1.
  • 2.
    TARGETS  INTRODUCTION  INDICATIONS EQUIPMENT  PROCEDURE  COMPLICATIONS  NORMAL LV ANGIOGRAM  CALCULATION OF LV FUNCTION  MITRAL REGURGITATION  VSD  SPOTTERS
  • 3.
    INTRODUCTION  In 1929Werner Forssman, inserted a urologic catheter into his right atrium from a left antecubital vein cut down he had performed on himself using a mirror.  Retrograde left heart catheterization was first done by Zimmerman,Limon Lason & Bouchard in 1950’s (Nobel prize in 1956).  Used to be the only method available for assessing LV segmental dysfunction.
  • 4.
    INDICATIONS  Define theanatomy and function of left ventricle.  Global and segmental LV function-qualitative and quantitative  Mitral valvular regurgitation  Congenital heart disease –VSD  Cardiomyopathy  LV non compaction.
  • 5.
    EQUIPMENT  1.INJECTION CATHETERS -largeamount of contrast in short period of time. -6F/7F/8F catheter with multiple side holes. -angled(145-155) pigtail catheters -straight tip ventriculographic catheters- sones catheter, NIH,eppendorf catheters,Lehmann catheter. -Balloon tip ventriculographic catheters- Berman
  • 6.
    Equipment.. 2.Power injectors –flow injectors (Medrad) - volume and rate of delivery can be selected - maximal pressure limit of 1000psi - can be synchronised with R wave - hand injection should be avoided.
  • 7.
    EQUIPMENT…  3.Biplane ventriculography betterthan single plane ventriculography. -more information at no additional risk. -single injection of contrast.  Disadvantages- higher cost additional time Reduced quality of cineangiographic images
  • 8.
    PROCEDURE  Approach toLV– Retro aortic ,injection directly into the ventricles Anterograde/trans septal approach Apical left ventricular puncture  Optimal catheter position –midcavitary adequate delivery to body and apex will not interfere with MV function less endocardial staining and ventricular ectopy
  • 9.
    PROCEDURE..  Cine leftventriculography with contrast vol – 30-36ml rate – 10-12ml/sec(pig tail) - 7-10 ml/sec(sones)  Older imaging systems required image acquisition at deep inspiration.  Newer imaging systems permits imaging during normal quite breathing.
  • 10.
    FILMING PROJECTION ANDTECHNIQUE  Cine left ventriculography – 15-30 frames/sec  Typically 30 deg RAO and 60 deg LAO views are obtained  30 deg RAO eliminates overlap of LV and the vertebral column anterior apical inferior segmental wall motion mitral valve profile ideal for assessment of MR
  • 11.
    FILMING PROJECTION..  60deg LAO - assess ventricular septal integrity and motion - lateral and posterior segmental function - aortic valvular anatomy -15-30 deg cranial angulation for profiling entire IVS
  • 12.
    VIEWS FOR SPECIFICCONDITIONS CONDITION VIEW LV FUNCTION 30 RAO/60 LAO MEMBRANOUS VSD 70 LAO 30 CRANIAL / RAO MUSCULAR VSD 4-C PROJECTION(45LAO-45CRANIAL) 70 LAO 30 CRANIAL / RAO AVSD 4-C PROJECTION(45LAO-45CRANIAL) 45RAO-45CRANIAL LVOTO 70 LAO 30 CRANIAL / RAO DORV 70 LAO 30 CRANIAL / RAO D-TGA 70 LAO 30 CRANIAL / RAO L-TGA RAO CRANIAL/LAO CRANIAL
  • 13.
  • 14.
    NORMAL LV ANGIOGRAM RAODIASTOLIC FRAME RAO SYSTOLIC FRAME
  • 15.
  • 16.
    LV FUNCTION ASSESSMENT Cineventriculography was the first method introduced in the routine practice to determine the LVEF.  The area-length technique is the most widely used method to quantify the left ventricular diastolic and systolic volumes.
  • 17.
    LV FUNCTION ASSESSMENT MEASURE Ventricular dimension Area Wall thickness  DERIVE Chamber volume Ejection Fraction LV mass LV wall stress
  • 18.
    STEPS IN LVVOLUME CALCULATION  1.Tracing LV outline or silhoutte  2.Marking aortic valve border  3.Calculation of LV volume by computer based algorithms  4.Magnification correction  5.Applying Regression Equation
  • 19.
     Angiographic stroke volume,SV= EDV – ESV  Ejection fraction,EF = (EDV – ESV) / EDV  LV wall thickness,h is measured at end diastole at LV free wall 2/3 distance from aortic valve to apex in RAO  LV Mass = Vc+w - VC CALCULATION OF LV MASSCALCULATION OF LV EF
  • 20.
  • 21.
  • 22.
    REGIONAL LV DYSFUNCTION Regional wall motion can be graded qualitatively as normal, hypokinetic, akinetic, dyskinetic,or hyperkinetic.  The analyses of the RAO and LAO projections as the following segments:
  • 23.
    REGIONAL LV DYSFUNCTION… CORONARYARTERY SEGMENTS LAD Anterolateral Apical Septal Diagonal branches Anterolateral Ramus intermedius Anterolateral Superolateral Left circumflex (dominant RCA) Posterolateral Superolateral Dominant right coronary artery Posterobasal Diaphragmatic Inferolateral
  • 24.
    MITRAL REGURGITATION  Diagnosisand assessment of severity of MR DEGREE VENTRICULOGRAPHIC CRITERIA 1+ Faint opacification of the left atrium with clearing of contrast during each beat 2+ Opacification of the atrium that does not clear but is not as dense as the left ventricle 3+ Opacification of the atrium with the same density as the ventricle 4+ Immediate, dense opacification of the atrium with filling of the pulmonary veins
  • 25.
    MR - REGURGITANTFRACTION  Angiographic quantification of MR  Total Stroke Volume (TSV = EDV – ESV) calculated from LVgram.  Forward Stroke Volume(FSV) calculated by Fick method or indicator dilution technique.  Regurgitant Stroke Volume (RSV) = TSV – FSV  Regurgitant Fraction (RF) = RSV/TSV ANGIO GRADE DOPPLER RF(%) ANGIO RF(%) 1 28 +/- 9 <20 2 38 +/- 9 21 - 40 3 44 +/- 10 41 - 60 4 59 +/- 12 >60
  • 26.
  • 27.
    HYPERTROPHIC CARDIOMYOPATHIES  InHCM, cavity obliteration is commonly seen together with small ventricular end- systolic volumes .  Systolic anterior motion of the mitral valve may result in severe degrees of mitral regurgitation.  The ventriculogram in the apical variant typically appears with a “spade”- shaped contour.
  • 28.
    TAKO TSUBO CARDIOMYOPATHY Diffuse akinesis of LV apex with preserved basal contractilty.  Characteristically resemble the shape of a japanese octopus trap(tako-tsubo)
  • 29.
    VENTRICULAR SEPTAL DEFECT A standard view in the evaluation of patients with ASDs or muscular VSDs is the hepatoclavicular view at 30◦ to 45◦ LAO and 30◦ to 45◦ cranial
  • 30.
    COMPLICATIONS…  Ventricular extrasystole– mechanical stimulation  Ventricular tachycardia – mostly NSVT  Intramyocardial injection/endocardial staining  Myocardial perforation  Left anterior fascicular block  Transient complete heart block  Embolism- air/thrombus  Complications of contrast media
  • 31.
  • 32.
  • 33.
  • 34.
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  • 36.
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  • 38.
  • 39.
  • 40.
    SPOTTER 10 “STACK OFCOINS” APPEARANCE
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  • 50.